Excellence in Bioengineering

Specialty Fatty Acids through
Synthetic Biology!

Synthetic biology and metabolic engineering allow us to build proprietary yeast platform strains. Using genome editing tools, standardized DNA parts and high-throughput screening methods, we can create and improve microbial cells for production of different bioactive ingredients.

Fatty Acid Products through Biotechnology and Yeast Bioengineering

Bioengineered Yeast cells transofrm sugar feedstocks into high value products

Yeast cells naturally consume sugars found in plant sources and produce alcohol from it. That process is known as "fermentation" and it is the core technology behind beer and wine brewing or bread making. Simply put, we engineer yeast cells so that they can produce different fatty acid-derived products, instead of alcohol! From that point on, the process is similar: yeasts ferment sugars and produce your high-value products!

The Process, Explained

Bakers' Yeast

The common bakers’ yeast, S. cerevisiae, is well know in history for its spotlight in fermenting beer, wine and bread. It’s native specialization is to consume different sugars available in nature and transform them to alcohol.

Saccharomyces cerevisiae

Repurposing Yeast

Yeast cells are robust and reliable industrial workhorses. Maybe for that, yeast has been adapted through biotechnology to be the catalyst of choice in very different industries, such as bioethanol and insulin production.

We take a step forward on this process and engineer yeast at its core for the production of specialty fatty acids with versatile properties.

Metabolism, Rewired

Metabolism is a network of pathways through which molecules flow. By redirecting the metabolism network inside the yeast cell, the cell can now convert natural sugars into fatty acid precursor molecules.

Enzymes, Pathways and Biobricks for yeast bioengineering and strain development

Plug & Play Parts

The fatty acid precursors formed inside the yeast cell can be converted into many different products.

The specific product formed will depend on the pathway modifying the fatty acid molecule. By using a library of genetic parts, we can produce different fatty acids and fatty acid-derived products using the same initial platform.

Iterative Improvement Cycle

Through iterative cycles and state-of-the art technology, we are able to use synthetic biology tools to create and screen different yeast cell designs. We can then understand which designs work best and repeat the process.

All this process enables better designs, a faster build process and methods for testing in a high-throughput fashion.

Our Technology in 3 Core Segments

The Yeast Platform

Metabolically rewired yeast cells able to produce high levels of relevant fatty acids or precursors.

Biotechnology production of Fatty Acids, Fatty Alcohols, Hydroxy Fatty Acids, Hydrocarbons, Dicarboxylic acids, Fatty Esters and Triglycerides

Plug & Play Parts

Libraries of parts such as fatty acid-modifying enzymes, pathways and biobricks. These can be combined with the yeast platform to produce thousands of different products.

Optimization Cycle

Iterative cycle to screen and optimize production of desired molecules through high-throughput technologies.

What Products Can We Create?

  • Fatty Acids
  • Hydrocarbons
  • Fatty Alcohols
  • Dicarboxylic Acids
  • Triglycerides
  • Hydroxy-Fatty Acids
  • Fatty Esters
  • ... and many other combinations and variations

The Tools that Make It Possible

Design

Rational Design & Computational Tools

Modelling

Protein Allocation

Target Prediction

Build

Synthetic Biology Toolbox

Expression Systems

Pathway Control

Enzyme Libraries

Test

Screening & Characterization

Biosensors

Metabolomics

Controlled Biorreactors